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Allantoin formation and urate and glutathione exchange in human muscle during submaximal exercise

Science 343 , 11331136, (2014)

Since the electrochemical determination of substances contained in the sample requires the presence of an electrolyte, we examined the effect of the organic solvent (methanol) on the electrochemical response of analytes

The researchers confirmed that both patient cohorts exhibit profound signs of elevated oxidative stress, particularly in memory T-cells, alongside severe decreases in mitochondrial superoxide dismutase protein levels and elevated lipid oxidative damage